Treating Complex Mental Health Conditions with Mindfulness, Acceptance, and Self-Compassion

Edited by Brandon A. Gaudiano, Mårten J. Tyrberg, and Jessica L. Kingston
Foreword by Stefan G. Hofmann

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October 6, 2026
ISBN 9781462563937
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353 Pages
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This timely practitioner handbook and text explores how to apply cutting-edge third-wave and process-based therapies to the real-world complexity that clinicians face daily. International experts describe ways they are using mindfulness, acceptance, and self-compassion in recovery-oriented treatment of challenging and co-occurring mental health conditions. Featuring accessible case examples and transdiagnostic therapeutic strategies, the book presents evidence-based tools to target underlying processes of change and help clients live in alignment with their values. Chapters include sidebars on specific techniques and practices, topic boxes, and resource lists with articles, manuals, and websites for further learning.

“The editors have brought together leading international experts in third-wave behavior therapy to stretch the boundaries of existing treatments. The book addresses a full range of complex, often hard-to-treat disorders and problems in living. There is no finer compilation of clinical wisdom on empirically supported applications of mindfulness, acceptance, and self-compassion.”

—Steven D. Hollon, PhD, Gertrude Conaway Vanderbilt Professor of Psychology, Vanderbilt University


“This volume offers therapists an innovative, insightful, process-driven framework for grappling with complex clinical presentations. Moving beyond symptoms and comorbid diagnoses, the book makes a compelling case for therapy that engages idiographic, dynamic change processes. Applications of mindfulness, acceptance, and self-compassion are amply illustrated through clinical transcripts and examples. This book will be of broad interest to therapists and students who want to learn about the cutting edge of third-wave treatments.”

—Zindel Segal, PhD, Distinguished Professor of Psychology in Mood Disorders, University of Toronto–Scarborough, Canada


“There is often a considerable gap between psychotherapy texts describe and what actually happens in therapy rooms. Clients rarely present with a single, well-defined disorder; therapists are guided by competing priorities; and therapy follows its own organic course. This substantial volume addresses that gap directly and honestly, capturing a pivotal moment in the field—the move from disorder-specific protocols toward process-based, transdiagnostic practice. The consistent structure across chapters—population, evidence, case example, in-depth technique, limitations, resources—makes the book genuinely usable and valuable for therapists and therapists in training.”

—Willem Kuyken, PhD, Ritblat Professor of Mindfulness and Psychological Science, University of Oxford, United Kingdom

Table of Contents

Foreword, Stefan G. Hofmann

I. Foundations and Core Processes

1. Navigating Rough Waters: Third-Wave Strategies for Complex Clinical Care, Brandon A. Gaudiano, Jessica L. Kingston, & Mårten J. Tyrberg

2. Common Processes for Promoting Recovery: Acceptance, Mindfulness, Self-Compassion, and Values, Jessica L. Kingston, Mårten J. Tyrberg & Brandon A. Gaudiano

II. Applications to Complex Clinical Presentations

Section 1: Mood- and Trauma-Related Conditions

3. Mindfulness-Based Cognitive Therapy for Persistent and Recurrent Depression, Thorsten Barnhofer

4. Emotion Regulation Therapy for Complex Distress Disorders, Jacob D. Kraft, Douglas S. Mennin, & David M. Fresco

5. Acceptance and Commitment Therapy for Complex Trauma, Sharon Stovezky & Robyn D. Walser

6. Compassion-Focused Therapy for Bipolar Disorder, Angela Foster, Rhiannon Murden, Elizabeth Newton, Hannah Vince, Abbie Bull, Andrew Rayner, Jaskaran Basran, Alison Hayes, Kaylie Sunshine, & Paul Gilbert

Section 2: Cross-Cutting Clinical Concerns

7. Contextual Behavioral Approaches for Neurodevelopmental Disabilities, Jordan Belisle & Alison Stapleton

8. Acceptance and Commitment Therapy for Preventing Suicide and Promoting Valued Living, Sean M. Barnes, Lauren M. Borges, Geoffrey Smith, Nazanin H. Bahraini, & Robyn D. Walser

9. Acceptance and Commitment Therapy for the Prevention and Treatment of Violent Behavior, Amie Zarling & Meg Berta

Section 3: Enduring and Persistent Problem Areas

10. Third-Wave Approaches for Psychosis and Its Complexities, Eric M. J. Morris, Daniel D. Simsion, & Julia D. Nicholls

11. Radically Open Dialectical Behavior Therapy for Overcontrolled Personality Disorders, Roelie J. Hempel & Michael Maslar

12. Acceptance and Commitment Therapy for Chronic Pain, Kevin E. Vowles & Bronwyn Lennox Thompson

III. Synthesis and Future Directions

13. Finding the Common Thread: Process-Based Tools for Transdiagnostic Practice, Mårten J. Tyrberg, Brandon A. Gaudiano, & Jessica L. Kingston

Index


About the Editors

Brandon A. Gaudiano, PhD, has dual roles as Professor in the Department of Psychiatry and Human Behavior at the Warren Alpert Medical School of Brown University and Professor in the Department of Behavioral and Social Sciences at the Brown School of Public Health. He is Director of the Transitional Outpatient Program and Associate Director of the Psychosocial Research Program at Butler Hospital, a research psychologist at the Providence VA Medical Center, and a core faculty member at the Brown Mindfulness Center. Dr. Gaudiano's research focuses on developing and testing innovative psychosocial treatments for mood and psychotic disorders. With over 200 publications, he is a Fellow of the American Psychological Association (APA) and serves on APA's Council of Representatives.

Mårten J. Tyrberg, PhD, is a clinical psychologist and postdoctoral researcher at the Hospital of Västmanland, the Centre for Clinical Research Västmanland, and Uppsala University, in Sweden. Dr. Tyrberg works clinically in psychiatric inpatient care, treating and assessing patients with various complex diagnoses. He is Adjunct Lecturer in the Department of Psychology, Uppsala University, and is affiliated with Karolinska Institute. Dr. Tyrberg's research focuses on psychological treatment in inpatient and acute psychiatric care and related areas. Recent publications have covered ultra-brief inpatient acceptance and commitment therapy for psychosis, cognitive-behavioral therapy for institutionalized youth, and implementation of the Safewards model.

Jessica L. Kingston, PhD, DClinPsy, is Research Director of the Doctorate in Clinical Psychology Program at Royal Holloway, University of London, United Kingdom. Her research focuses on advancing the scientific understanding of third-wave psychological interventions across the spectrum of mild to severe mental health difficulties. Dr. Kingston has particular expertise in paranoia, for which she has developed and delivered novel treatments in both U.K. National Health Service and community settings, including the creation and evaluation of clinician-led and digitally delivered treatment manuals. Dr. Kingston is currently pioneering research on paranoia in adolescents, with a strong emphasis on early identification and intervention.

Audience

Practitioners, trainees, and graduate students in clinical psychology, clinical social work, psychiatric nursing, counseling, and psychiatry.

Course Use

Will serve as a text in graduate-level courses such as Evidence-Based Mental Health Practice and Treatment of Serious Mental Illness